Evaluating the In Vivo Specificity of [<sup>18</sup>F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET

Evaluating the In Vivo Specificity of [<sup>18</sup>F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET

The synaptic vesicle protein 2 (SV2) is involved in synaptic vesicle trafficking. The SV2A isoform is the most studied and its implication in epilepsy therapy led to the development of the first SV2A PET radiotracer [<sup>18</sup>F]UCB-H. The objective of this study was to evaluate in vi...

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Bibliographic Details
Main Authors: Maria Elisa Serrano, Guillaume Becker, Mohamed Ali Bahri, Alain Seret, Nathalie Mestdagh, Joël Mercier, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, Eric Salmon, André Luxen, Alain Plenevaux
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
SV2A
SV2B
SV2C
microPET
[<sup>18</sup>F]UCB-H
epilepsy
PBIF
distribution volume
blocking assay
preclinical imaging
Online Access:https://www.mdpi.com/1420-3049/24/9/1705

Internet

https://www.mdpi.com/1420-3049/24/9/1705

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