High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

Human monoamine oxidase B (hMAO-B) has emerged as a pivotal therapeutic target for Parkinson's disease. Due to adverse effects and shortage of commercial drugs, there is a need for novel, highly selective, and reversible hMAO-B inhibitors with good blood-brain barrier permeability. In this stud...

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Bibliographic Details
Main Authors: Yu Fan, Jincai Wang, Jingyi Jian, Yalei Wen, Jiahao Li, Hao Tian, Jacques Crommen, Wei Bi, Tingting Zhang, Zhengjin Jiang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Human monoamine oxidase B inhibitors
High-throughput screening
At-line nanofractionation
Parkinson's disease
Cellular neuroprotection
Traditional Chinese medicines (TCMs)
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524000352

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http://www.sciencedirect.com/science/article/pii/S2211383524000352

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