Fiber pathway pathology, synapse loss and decline of cortical function in schizophrenia.

A quantitative cortical model is developed, based on both computational and simulation approaches, which relates measured changes in cortical activity of gray matter with changes in the integrity of longitudinal fiber pathways. The model consists of modules of up to 5,000 neurons each, 80% excitator...

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Bibliographic Details
Main Authors: Max R Bennett, Les Farnell, William G Gibson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3620229?pdf=render