Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder.

Disease-associated mutations disrupt functionally important regions of intrinsic protein disorder.

The effects of disease mutations on protein structure and function have been extensively investigated, and many predictors of the functional impact of single amino acid substitutions are publicly available. The majority of these predictors are based on protein structure and evolutionary conservation...

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Bibliographic Details
Main Authors: Vladimir Vacic, Phineus R L Markwick, Christopher J Oldfield, Xiaoyue Zhao, Chad Haynes, Vladimir N Uversky, Lilia M Iakoucheva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3464192?pdf=render

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http://europepmc.org/articles/PMC3464192?pdf=render

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