A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus

A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus

IntroductionThe role of suppressor of cytokine signaling (SOCS)2 in anti-infective bacterial immunity has been poorly investigated compared to other members of the SOCS family.MethodsWe characterized the previously identified loss of function R96C point mutation of SOCS2 using a genome-edited mouse...

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Bibliographic Details
Main Authors: Laurence Guzylack-Piriou, Blandine Gausseres, Christian Tasca, Chervin Hassel, Guillaume Tabouret, Gilles Foucras
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
SOCS2
R96C mutation
inflammatory response
macrophages
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397330/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397330/full

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