Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity

Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity

T cell activation and effector function is mediated by the formation of a long-lasting interaction established between T cells and antigen-presenting cells (APCs) called immunological synapse (IS). During T cell activation, different signaling molecules as well as the cytoskeleton and the endosomal...

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Bibliographic Details
Main Authors: Patricia Castro-Sánchez, Oscar Aguilar-Sopeña, Sergio Alegre-Gómez, Rocio Ramirez-Munoz, Pedro Roda-Navarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
PTP
T cell activation
intracellular signaling
cytoskeleton
endosomal compartment
immunological synapse
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01447/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01447/full

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