PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells

PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells

Despite comprehensive therapy and extensive research, glioblastoma (GBM) still represents the most aggressive brain tumor in adults. Glioma stem cells (GSCs) are thought to play a major role in tumor progression and resistance of GBM cells to radiochemotherapy. The PIM1 kinase has become a focus in...

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Bibliographic Details
Main Authors: Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gaßmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen V. Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Möller
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
PIM1 kinase
stem-like cells
neurospheres
Online Access:https://www.mdpi.com/1422-0067/22/20/11126

Internet

https://www.mdpi.com/1422-0067/22/20/11126

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