Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.

Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.

K-ras is essential for embryogenesis and its mutations are involved in human developmental syndromes and cancer. To determine the consequences of K-ras activation in urothelium, we used uroplakin-II (UPK II) promoter driven Cre recombinase mice and generated mice with mutated KrasG12D allele in the...

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Bibliographic Details
Main Authors: Francisco Ayala de la Peña, Keizo Kanasaki, Megumi Kanasaki, Sylvia Vong, Carlota Rovira, Raghu Kalluri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095888&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095888&type=printable

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