The Impact of X-Chromosome Inactivation on Phenotypic Expression of X-Linked Neurodevelopmental Disorders

Nearly 20% of genes located on the X chromosome are associated with neurodevelopmental disorders (NDD) due to their expression and role in brain functioning. Given their location, several of these genes are either subject to or can escape X-chromosome inactivation (XCI). The degree to which genes ar...

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Bibliographic Details
Main Authors: Boudewien A Brand, Alyssa E Blesson, Constance L. Smith-Hicks
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/11/7/904