Immune Protection of SIV Challenge by PD-1 Blockade During Vaccination in Rhesus Monkeys

Immune Protection of SIV Challenge by PD-1 Blockade During Vaccination in Rhesus Monkeys

Though immune correlates for protection are still under investigation, potent cytotoxic T lymphocyte responses are desirable for an ideal HIV-1 vaccine. PD-1 blockade enhances SIV-specific CD8+ T cells. However, little information has been reported about how it affects the immunogenicity and protect...

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Bibliographic Details
Main Authors: Enxiang Pan, Fengling Feng, Pingchao Li, Qing Yang, Xiuchang Ma, Chunxiu Wu, Jin Zhao, Hongbin Yan, Rulei Chen, Ling Chen, Caijun Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
PD-1 blockade
HIV vaccine
CTL
NHP model
SIV challenge
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02415/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02415/full

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