IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice

IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice

Abstract Objective To assess the impact of the IFIT3/TBK1 signalling pathway in activating plasmacytoid dendritic cells (pDCs) and its role in the development of SSc. Methods Utilized single‐cell RNA sequencing (scRNA‐seq) and high‐throughput transcriptome RNA sequencing to reveal the differential a...

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Bibliographic Details
Main Authors: Xiangyang Huang, Yi Liu, Xia Rong, Yiheng Zhao, Dan Feng, Jun Wang, Wanhong Xing
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Clinical and Translational Medicine
Subjects:
CRISPR/Cas9
fibrosis
IFIT3/TBK1 signalling pathway
pDCs activation
scRNA‐seq
systemic sclerosis
Online Access:https://doi.org/10.1002/ctm2.1800

Internet

https://doi.org/10.1002/ctm2.1800

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