Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A
The blood vessel wall is a complex multi-layered structure, yet upon injury or infection, neutrophil leukocytes are rapidly migrating from the blood stream to the affected tissues, by a process termed diapedesis. Authors here show that the final steps of diapedesis through the outer pericyte layer i...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34695-7 |
| _version_ | 1811217085680844800 |
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| author | Régis Joulia Idaira María Guerrero-Fonseca Tamara Girbl Jonathon A. Coates Monja Stein Laura Vázquez-Martínez Eleanor Lynam James Whiteford Michael Schnoor David Voehringer Axel Roers Sussan Nourshargh Mathieu-Benoit Voisin |
| author_facet | Régis Joulia Idaira María Guerrero-Fonseca Tamara Girbl Jonathon A. Coates Monja Stein Laura Vázquez-Martínez Eleanor Lynam James Whiteford Michael Schnoor David Voehringer Axel Roers Sussan Nourshargh Mathieu-Benoit Voisin |
| author_sort | Régis Joulia |
| collection | DOAJ |
| description | The blood vessel wall is a complex multi-layered structure, yet upon injury or infection, neutrophil leukocytes are rapidly migrating from the blood stream to the affected tissues, by a process termed diapedesis. Authors here show that the final steps of diapedesis through the outer pericyte layer is regulated by perivascular mast cells via IL-17A production. |
| first_indexed | 2024-04-12T06:49:13Z |
| format | Article |
| id | doaj.art-84b97690afca49fa86cbd85337ff0f72 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T06:49:13Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-84b97690afca49fa86cbd85337ff0f722022-12-22T03:43:26ZengNature PortfolioNature Communications2041-17232022-11-0113111610.1038/s41467-022-34695-7Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17ARégis Joulia0Idaira María Guerrero-Fonseca1Tamara Girbl2Jonathon A. Coates3Monja Stein4Laura Vázquez-Martínez5Eleanor Lynam6James Whiteford7Michael Schnoor8David Voehringer9Axel Roers10Sussan Nourshargh11Mathieu-Benoit Voisin12William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareDepartment of Molecular Biomedicine, CINVESTAV-IPNDepartment of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU)Institute for Immunology, Heidelberg University HospitalWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareWilliam Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse SquareThe blood vessel wall is a complex multi-layered structure, yet upon injury or infection, neutrophil leukocytes are rapidly migrating from the blood stream to the affected tissues, by a process termed diapedesis. Authors here show that the final steps of diapedesis through the outer pericyte layer is regulated by perivascular mast cells via IL-17A production.https://doi.org/10.1038/s41467-022-34695-7 |
| spellingShingle | Régis Joulia Idaira María Guerrero-Fonseca Tamara Girbl Jonathon A. Coates Monja Stein Laura Vázquez-Martínez Eleanor Lynam James Whiteford Michael Schnoor David Voehringer Axel Roers Sussan Nourshargh Mathieu-Benoit Voisin Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A Nature Communications |
| title | Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A |
| title_full | Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A |
| title_fullStr | Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A |
| title_full_unstemmed | Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A |
| title_short | Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A |
| title_sort | neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell derived il 17a |
| url | https://doi.org/10.1038/s41467-022-34695-7 |
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