Enhanced Levels of Peroxisome-Derived H<sub>2</sub>O<sub>2</sub> Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

Enhanced Levels of Peroxisome-Derived H<sub>2</sub>O<sub>2</sub> Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-producing and -degrading enzymes. Given that this oxidant functions as a major redox signaling agent, peroxisomes have the intrinsic ability to mediate and...

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Bibliographic Details
Main Authors: Hongli Li, Celien Lismont, Cláudio F. Costa, Mohamed A. F. Hussein, Myriam Baes, Marc Fransen
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antioxidants
Subjects:
peroxisomes
hydrogen peroxide
pexophagy
autophagy
oxidative stress
mKeima
Online Access:https://www.mdpi.com/2076-3921/12/3/613

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