Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat

Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat

Hexafluoropropylene oxide dimer acid (HFPO-DA or GenX) is an industrial replacement for the straight-chain perfluoroalkyl substance (PFAS), perfluorooctanoic acid (PFOA). Previously we reported maternal, fetal, and postnatal effects from gestation day (GD) 14-18 oral dosing in Sprague-Dawley rats. H...

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Bibliographic Details
Main Authors: Justin M. Conley, Christy S. Lambright, Nicola Evans, James McCord, Mark J. Strynar, Donna Hill, Elizabeth Medlock-Kakaley, Vickie S. Wilson, L. Earl Gray, Jr.
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Environment International
Subjects:
PFAS
Developmental toxicity
In utero exposure
Peroxisome proliferator-activated receptor
Low birthweight
Glucose metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412020321590

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http://www.sciencedirect.com/science/article/pii/S0160412020321590

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