Choosing an Optimal Solvent Is Crucial for Obtaining Cell-Penetrating Peptide Nanoparticles with Desired Properties and High Activity in Nucleic Acid Delivery

Choosing an Optimal Solvent Is Crucial for Obtaining Cell-Penetrating Peptide Nanoparticles with Desired Properties and High Activity in Nucleic Acid Delivery

Cell-penetrating peptides (CPPs) are highly promising transfection agents that can deliver various compounds into living cells, including nucleic acids (NAs). Positively charged CPPs can form non-covalent complexes with negatively charged NAs, enabling simple and time-efficient nanoparticle preparat...

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Bibliographic Details
Main Authors: Abhijit Biswas, Maria Maloverjan, Kärt Padari, Aare Abroi, Margus Rätsep, Sebastian K. T. S. Wärmländer, Jüri Jarvet, Astrid Gräslund, Vambola Kisand, Rünno Lõhmus, Margus Pooga
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
cell-penetrating peptides
solvent
nanoparticle formation
nucleic acid delivery
Online Access:https://www.mdpi.com/1999-4923/15/2/396

Internet

https://www.mdpi.com/1999-4923/15/2/396

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