Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy

Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy

Summary: Non-natural nucleobase isocytosine (IC) is the isomer of cytosine; its chemical derivate 5-fluoroisocytosine (5-FIC) together with the isocytosine-specific deaminase (ICD) VCZ was suggested to be potential practical enzyme/prodrug pair for cancer therapy through gene-directed enzyme-prodrug...

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Bibliographic Details
Main Authors: Wenting Guo, Xiaojia Li, Jingyu Fan, Hongwei Li, Yan Wen, Chunyan Meng, Haitao Chen, Zhipeng Zhao, Yuling Zhang, Yushen Du, Baixing Wu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Pharmacology
Natural sciences
Biological sciences
Biochemistry
Biomolecules
Protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223017492

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http://www.sciencedirect.com/science/article/pii/S2589004223017492

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