A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT<sub>2A</sub> Receptor Density in the Pig Brain

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT<sub>2A</sub> Receptor Density in the Pig Brain

A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT<sub>2A</sub>R) agonist, may be associated with antidepressant effects. The mechanism behind its antidepressive action is unknown but could be linked to increased synaptogenesis and down-regulation of cerebral 5-HT...

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Bibliographic Details
Main Authors: Nakul Ravi Raval, Annette Johansen, Lene Lundgaard Donovan, Nídia Fernandez Ros, Brice Ozenne, Hanne Demant Hansen, Gitte Moos Knudsen
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
psilocybin
psychedelics
neuroplasticity
SV2A
5-HT2A
depression
Online Access:https://www.mdpi.com/1422-0067/22/2/835

Internet

https://www.mdpi.com/1422-0067/22/2/835

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