Housing of A350V IQSEC2 pups at 37 °C ambient temperature prevents seizures and permits the development of social vocalizations in adulthood

Housing of A350V IQSEC2 pups at 37 °C ambient temperature prevents seizures and permits the development of social vocalizations in adulthood

Objectives Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human IQSEC2 missense mutation (A350V) for which we have created a corresponding A350V IQSEC2 mouse model by CRISPR which demonstrates sei...

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Bibliographic Details
Main Authors: Reem Jada, Liron Zag, Veronika Borisov, Nina S. Levy, Shai Netser, Renad Jabarin, Shlomo Wagner, Kinneret Schragenheim-Rozales, Reut Shalgi, Andrew P. Levy
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:International Journal of Hyperthermia
Subjects:
iqsec2
epilepsy
lethal seizures
ultrasonic vocalizations
Online Access:http://dx.doi.org/10.1080/02656736.2021.1988730

Internet

http://dx.doi.org/10.1080/02656736.2021.1988730

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