Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice

Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice

There is accumulating evidence that pathogenic T cells in T1D recognize epitopes formed by post-translational modifications of β-cell antigens, including hybrid insulin peptides (HIPs). The ligands for several CD4 T-cell clones derived from the NOD mouse are HIPs composed of a fragment of proinsulin...

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Bibliographic Details
Main Authors: Janet M. Wenzlau, Orion J. Peterson, Anthony N. Vomund, James E. DiLisio, Anita Hohenstein, Kathryn Haskins, Xiaoxiao Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
autoimmune diabetes
type 1 diabetes
hybrid insulin peptide
antigen
post-translational modification
NOD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348131/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348131/full

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