Germline Mutation in <i>MUS81</i> Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer

Germline Mutation in <i>MUS81</i> Resulting in Impaired Protein Stability is Associated with Familial Breast and Thyroid Cancer

Multiple primary thyroid cancer (TC) and breast cancer (BC) are commonly diagnosed, and the lifetime risk for these cancers is increased in patients with a positive family history of both TC and BC. Although this phenotype is partially explained by <i>TP53</i> or <i>PTEN</i>...

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Main Authors: Maisa Pinheiro, Fernanda Cristina Sulla Lupinacci, Karina Miranda Santiago, Sandra Aparecida Drigo, Fabio Albuquerque Marchi, Carlos Eduardo Fonseca-Alves, Sonia Cristina da Silva Andrade, Mads Malik Aagaard, Tatiane Ramos Basso, Mariana Bisarro dos Reis, Rolando André Rios Villacis, Martin Roffé, Glaucia Noeli Maroso Hajj, Igor Jurisica, Luiz Paulo Kowalski, Maria Isabel Achatz, Silvia Regina Rogatto
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
exome sequencing
<i>MUS81</i>
breast cancer
thyroid cancer
functional analysis
familial cancer
Online Access:https://www.mdpi.com/2072-6694/12/5/1289

Internet

https://www.mdpi.com/2072-6694/12/5/1289

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