Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells

Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells

Diminished regeneration or healing capacity of tendon occurs during aging. It has been well demonstrated that tendon stem/progenitor cells (TSPCs) play a vital role in tendon maintenance and repair. Here, we identified an accumulation of senescent TSPCs in tendon tissue with aging. In aged TSPCs, th...

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Manylion Llyfryddiaeth
Prif Awduron: Minhao Chen, Longfei Xiao, Guangchun Dai, Panpan Lu, Yuanwei Zhang, Yingjuan Li, Ming Ni, Yunfeng Rui
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Frontiers Media S.A. 2021-03-01
Cyfres:Frontiers in Cell and Developmental Biology
Pynciau:
tendon-derived stem/progenitor cells
tendon aging
senescence
JAK-STAT signaling pathway
AG490
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fcell.2021.650250/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.650250/full

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