Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Abstract Background Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFRβ could potentially allow the quantification of fibrogenesis in fibrotic livers. This study aims to ev...

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Bibliographic Details
Main Authors: Olivia Wegrzyniak, Bo Zhang, Johanna Rokka, Maria Rosestedt, Bogdan Mitran, Pierre Cheung, Emmi Puuvuori, Sofie Ingvast, Jonas Persson, Helena Nordström, John Löfblom, Fredrik Pontén, Fredrik Y. Frejd, Olle Korsgren, Jonas Eriksson, Olof Eriksson
Format: Article
Language:English
Published: SpringerOpen 2023-09-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
PET imaging
Platelet derived growth factor receptor
Hepatic stellate cells
Fibrogenesis
Liver fibrosis
Online Access:https://doi.org/10.1186/s41181-023-00210-6

Internet

https://doi.org/10.1186/s41181-023-00210-6

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