Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments

Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments

Objective: This work aims to explore the potential targets and underlying therapeutic mechanisms of celastrol in autoimmune hepatitis (AIH) through network pharmacology and experiments on Laboratory Animals.Methods: A drug-target interaction network was constructed to predict the possible targets of...

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Bibliographic Details
Main Authors: Shuhui Wang, Zheng Huang, Yu Lei, Xu Han, Dean Tian, Jin Gong, Mei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
celastrol
network pharmacology
autoimmune hepatitis
immunological disorders
PI3K/akt signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.816350/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.816350/full

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