Molecular Mechanisms of Anticancer Activity of N-Glycosides of Indolocarbazoles LCS-1208 and LCS-1269

Molecular Mechanisms of Anticancer Activity of N-Glycosides of Indolocarbazoles LCS-1208 and LCS-1269

Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo. We studied the mechanisms of anticancer activity in accordance with the previously described effects of indolocarbazoles. Cytotoxicity was estim...

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Bibliographic Details
Main Authors: Roman G. Zenkov, Olga A. Vlasova, Varvara P. Maksimova, Timur I. Fetisov, Natalia Y. Karpechenko, Lidiya V. Ektova, Vera A. Eremina, Valeriia G. Popova, Olga G. Usalka, Ekaterina A. Lesovaya, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
LCS-1208
LCS-1269
indolocarbazoles
antitumor activity
intercalation
chromatin remodeling
Online Access:https://www.mdpi.com/1420-3049/26/23/7329

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https://www.mdpi.com/1420-3049/26/23/7329

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