Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome

Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome

Sepsis refers to the systemic inflammatory response syndrome caused by infection. It is a major clinical problem and cause of death for patients in intensive care units worldwide. The Fat mass and obesity-related protein (FTO) is the primary N6-methyladenosine demethylase. However, the role of FTO i...

Full description

Bibliographic Details
Main Authors: Jiahui Luo, Faxi Wang, Fei Sun, Tiantian Yue, Qing Zhou, Chunliang Yang, Shanjie Rong, Ping Yang, Fei Xiong, Qilin Yu, Shu Zhang, Cong-Yi Wang, Jinxiu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
FTO
N6-methyladenosine
entacapone
inflammasome
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663295/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.663295/full

Similar Items