Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain

Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain

Single nucleotide variations in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) have been linked to both late-onset Alzheimer's disease and behavioral variant frontotemporal dementia (FTD), the latter presenting either in isolation or with cystic bone lesions in a condition called Nasu...

Full description

Bibliographic Details
Main Authors: Hunter B. Dean, Erik D. Roberson, Yuhua Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neurology
Subjects:
Alzheimer's disease
frontotemporal dementia
neurodegenerative disease
triggering receptor expressed on myeloid cells 2
innate immune receptor
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01252/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.01252/full

Similar Items