High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells

High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells

Summary: Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for CNS demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelination-promoting compounds, we generated a genome-engineered human pluripo...

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Bibliographic Details
Main Authors: Weifeng Li, Cynthia Berlinicke, Yinyin Huang, Stefanie Giera, Anna G. McGrath, Weixiang Fang, Chaoran Chen, Felipe Takaesu, Xiaoli Chang, Yukan Duan, Dinesh Kumar, Calvin Chang, Hai-Quan Mao, Guoqing Sheng, James C. Dodge, Hongkai Ji, Stephen Madden, Donald J. Zack, Xitiz Chamling
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Neuroscience
Cell biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300233X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422300233X

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