Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease

Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease

Epidemiological analyses indicate that type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD). They share common pathophysiological mechanisms. Thus, it has been increasingly suggested that several anti-T2DM drugs may have therapeutic potential in AD. Exendin-4, as a gluc...

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Bibliographic Details
Main Authors: Xiangwei Song, Yingqi Sun, Zhun Wang, Yingying Su, Yangkun Wang, Xueli Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
Exendin-4
Caenorhabditis elegans
DAF-16
Amyloid-β peptide
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.955113/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.955113/full

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