STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma

STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma

Abstract Chemotherapy resistance is the leading cause for hepatocellular carcinoma (HCC)-induced death. Exploring resistance generation mechanism is an urgent need for HCC therapy. Here, we found STEAP4 was significantly downregulated in HCC patients with recurrence. Patients with low STEAP4 had poo...

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Bibliographic Details
Main Authors: Binhui Xie, Baiyin Zhong, Zhenxian Zhao, Jie Hu, Jianqiong Yang, Yuankang Xie, Jianhong Zhang, Jianting Long, Xuewei Yang, Heping Li
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Cancer & Metabolism
Subjects:
STEPA4
Chemotherapy resistance
AKT
Hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s40170-023-00323-1

Internet

https://doi.org/10.1186/s40170-023-00323-1

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