Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways

Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways

Crassolide, a cembranoid diterpene extracted from the soft coral <i>Lobophytum crissum</i>, has been proven to possess antioxidant and immunomodulatory properties. In the present study, we assessed the anticancer effects of crassolide on human H460 non-small-cell lung cancer (NSCLC) cell...

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Bibliographic Details
Main Authors: Kuan-Ming Lai, Jou-Hsuan Wang, Shih-Chao Lin, Ya Wen, Chao-Liang Wu, Jui-Hsin Su, Chien-Chin Chen, Chi-Chien Lin
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
apoptosis
cell cycle
crassolide
soft coral
ER stress
Online Access:https://www.mdpi.com/1422-0067/23/10/5624

Internet

https://www.mdpi.com/1422-0067/23/10/5624

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