Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response

Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response

Abstract Background Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of T cell-subtype specific transgenic mouse models it now has become possible to study the complex...

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Bibliographic Details
Main Authors: Marius Piepke, Bettina H. Clausen, Peter Ludewig, Jonas H. Vienhues, Tanja Bedke, Ehsan Javidi, Björn Rissiek, Larissa Jank, Leonie Brockmann, Inga Sandrock, Karoline Degenhardt, Alina Jander, Vanessa Roth, Ines S. Schädlich, Immo Prinz, Richard A. Flavell, Yasushi Kobayashi, Thomas Renné, Christian Gerloff, Samuel Huber, Tim Magnus, Mathias Gelderblom
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Neuroinflammation
Subjects:
Stroke
Ischemia
Inflammation
T cells
Interleukin-10
Interleukin-17
Online Access:https://doi.org/10.1186/s12974-021-02316-7

Internet

https://doi.org/10.1186/s12974-021-02316-7

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