Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

Summary: The interplay between metabolism and chromatin signaling is implicated in cancer progression. However, whether and how metabolic reprogramming in tumors generates chromatin vulnerabilities remain unclear. Lung adenocarcinoma (LUAD) tumors frequently harbor aberrant activation of the NRF2 an...

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Bibliographic Details
Main Authors: Dimitris Karagiannis, Warren Wu, Albert Li, Makiko Hayashi, Xiao Chen, Michaela Yip, Vaibhav Mangipudy, Xinjing Xu, Francisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Jiangbin Ye, Thales Papagiannakopoulos, Chao Lu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016406

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http://www.sciencedirect.com/science/article/pii/S2211124723016406

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