Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1

Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1

Mitochondrial biogenesis and function are controlled by anterograde regulatory pathways involving more than 1000 nuclear-encoded proteins. Transcriptional networks controlling the nuclear-encoded mitochondrial genes remain to be fully elucidated. Here, we show that histone demethylase LSD1 KO from a...

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Bibliographic Details
Main Authors: Yang Cao, Lingyi Tang, Kang Du, Kitt Paraiso, Qiushi Sun, Zhengxia Liu, Xiaolong Ye, Yuan Fang, Fang Yuan, Hank Chen, Yumay Chen, Xiaorong Wang, Clinton Yu, Ira L. Blitz, Ping H. Wang, Lan Huang, Haibo Cheng, Xiang Lu, Ken W.Y. Cho, Marcus Seldin, Zhuyuan Fang, Qin Yang
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Endocrinology
Online Access:https://doi.org/10.1172/jci.insight.147692

Internet

https://doi.org/10.1172/jci.insight.147692

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