Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis

Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis

Pyruvate kinase deficiency is a rare hereditary erythrocyte enzyme disease caused by mutations in the pyruvate kinase liver and red blood cell gene. The clinical presentations of pyruvate kinase deficiency are significantly heterogeneous, ranging from just mild anemia to hemolytic crisis or even dea...

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Bibliographic Details
Main Authors: Yang Wang, Jiaqi Liu, Tao Liu, Xizhou An, Lan Huang, Jiacheng Li, Yongjie Zhang, Yan Xiang, Li Xiao, Weijia Yi, Jiebin Qin, Lili Liu, Cuilan Wang, Jie Yu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Mutation
Pyruvate kinase deficiency
Pyruvate kinase
Molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024023995

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http://www.sciencedirect.com/science/article/pii/S2405844024023995

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