GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma—Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis

GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma—Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis

Objective: Despite the use of surgical and chemoradiation therapies, head and neck squamous cell carcinoma (HNSCC) still has a poor prognosis. Immune checkpoint inhibitors have been shown to prolong life expectancy but have limited efficacy. Glycoprotein nonmetastatic melanoma protein B (GPNMB) has...

Full description

Bibliographic Details
Main Authors: Yohei Kawasaki, Hitomi Suzuki, Shinsuke Suzuki, Takechiyo Yamada, Maya Suzuki, Ayumi Ito, Haruka Hatakeyama, Masahito Miura, Yasufumi Omori
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Pathology and Oncology Research
Subjects:
epithelial-mesenchymal transition
cancer stem cells
radiotherapy
head and neck squamous cell carcinoma
glycoprotein nonmetastatic melanoma protein B
prognostic factor
Online Access:https://www.por-journal.com/articles/10.3389/pore.2022.1610450/full

Internet

https://www.por-journal.com/articles/10.3389/pore.2022.1610450/full

Similar Items