Validation of a pharmacological imaging challenge using 11C-buprenorphine and 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to study the effects of buprenorphine to the rat brain

Validation of a pharmacological imaging challenge using 11C-buprenorphine and 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to study the effects of buprenorphine to the rat brain

AimBuprenorphine mainly acts as an agonist of mu-opioid receptors (mu-OR). High dose buprenorphine does not cause respiratory depression and can be safely administered to elicit typical opioid effects and explore pharmacodynamics. Acute buprenorphine, associated with functional and quantitative neur...

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Bibliographic Details
Main Authors: Amélie Soyer, Sarah Leterrier, Louise Breuil, Maud Goislard, Claire Leroy, Wadad Saba, Karine Thibault, Gregory Dal Bo, Michel Bottlaender, Fabien Caillé, Sébastien Goutal, Nicolas Tournier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
addiction
neuroimaging
opioid
PET imaging
pharmacodynamics
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1181786/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1181786/full

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