Loss of CFTR function in macrophages alters the cell transcriptional program and delays lung resolution of inflammation

Loss of CFTR function in macrophages alters the cell transcriptional program and delays lung resolution of inflammation

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of CF occur in the lung, manifesting as chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airwa...

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Bibliographic Details
Main Authors: Dianne Wellems, Yawen Hu, Scott Jennings, Guoshun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
CFTR
macrophage-specific CF mouse model
lung infection and inflammation
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242381/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242381/full

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