Detailed Experimental and In Silico Investigation of Indomethacin Binding with Human Serum Albumin Considering Primary and Secondary Binding Sites

Detailed Experimental and In Silico Investigation of Indomethacin Binding with Human Serum Albumin Considering Primary and Secondary Binding Sites

The interaction of indomethacin with human serum albumin (HSA) has been studied here considering the primary and secondary binding sites. The Stern–Volmer plots were linear in the lower concentration range of indomethacin while a downward curvature was observed in the higher concentration range, sug...

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Bibliographic Details
Main Authors: Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Mohammad Tariq, Hamad A. Al-Lohedan, Abdullah Saad S. Al-Sanea
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
albumin
indomethacin
primary binding site
secondary binding site
fluorescence
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/28/7/2979

Internet

https://www.mdpi.com/1420-3049/28/7/2979

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