Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety

Abstract It is unclear whether and to what extent stress-related exposures moderate the effects of polygenic risk scores (PRSs) on depression and anxiety. We aimed to examine such moderation effects for a variety of stress-related exposures on depression and anxiety. We included 41,810 participants...

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Bibliographic Details
Main Authors: Rujia Wang, Lifelines Cohort Study, Catharina A. Hartman, Harold Snieder
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02327-3