Macrophage Depletion Lowered Blood Pressure and Attenuated Hypertensive Renal Injury and Fibrosis

Monocyte/macrophage recruitment is closely associated with the degree of hypertensive renal injury. We investigated the direct role of macrophages using liposome-encapsulated clodronate (LEC) to deplete monocytes/macrophages in hypertensive renal injury. C57BL/6 mice were treated with a pressor dose...

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Bibliographic Details
Main Authors: Lei Huang, Aimei Wang, Yun Hao, Weihong Li, Chang Liu, Zhihang Yang, Feng Zheng, Ming-Sheng Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
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Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00473/full