β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway

β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway

Intestinal mucositis (IM) is the main side effect observed in patients who receive cancer chemotherapy. The characteristics of ulceration, vomiting, and severe diarrhea cause patients to delay or abandon further treatment, thereby aggravating their progress. Hence, IM cannot be overlooked. β-patchou...

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Bibliographic Details
Main Authors: Jiazhen Wu, Yuxuan Gan, Huijuan Luo, Nan Xu, Liping Chen, Mengyao Li, Fengkun Guan, Ziren Su, Zhixiu Lin, Jianhui Xie, Yuhong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
intestinal mucositis
β-patchoulene
water transport
cAMP/PKA/CREB pathway
5-fluorouracil
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.689491/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.689491/full

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