Metabolic Syndrome and Male Fertility

Metabolic syndrome (MetS) represents a cluster of conditions that have a negative impact on human health overall. Its preva-lence has been rapidly increasing worldwide and has coincided with a global decrease in birth rates and fertility potential. This review aims to address this observation throug...

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Main Authors: Ana Dias Martins, Ahmad Majzoub, Ashok Agawal
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2019-05-01
Series:The World Journal of Men's Health
Subjects:
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author Ana Dias Martins
Ahmad Majzoub
Ashok Agawal
author_facet Ana Dias Martins
Ahmad Majzoub
Ashok Agawal
author_sort Ana Dias Martins
collection DOAJ
description Metabolic syndrome (MetS) represents a cluster of conditions that have a negative impact on human health overall. Its preva-lence has been rapidly increasing worldwide and has coincided with a global decrease in birth rates and fertility potential. This review aims to address this observation through studying the relationship between MetS and male reproductive health. The effects of obesity, dyslipidemia, hypertension, and insulin resistance on male fertility were examined and supporting evi-dence explaining the pathophysiology of sperm dysfunction with each MetS component were described. Adopting a healthy lifestyle appears to be the single most important intervention to prevent the unwanted effects of MetS on men’s health and fertility. Further studies addressing the components of MetS and their impact on male reproduction are required to enhance our understanding of the underlying pathophysiology and to propose new methods for therapeutic intervention.
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spelling doaj.art-84fddcfa33ce40a9bd99d19ac3572d072022-12-21T19:20:21ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902019-05-0137211312710.5534/wjmh.180055Metabolic Syndrome and Male FertilityAna Dias Martins0Ahmad Majzoub1Ashok Agawal2American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USADepartment of Urology, Hamad Medical Corporation and Weill Cornell Medicine-Qatar, Doha, QatarAmerican Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USAMetabolic syndrome (MetS) represents a cluster of conditions that have a negative impact on human health overall. Its preva-lence has been rapidly increasing worldwide and has coincided with a global decrease in birth rates and fertility potential. This review aims to address this observation through studying the relationship between MetS and male reproductive health. The effects of obesity, dyslipidemia, hypertension, and insulin resistance on male fertility were examined and supporting evi-dence explaining the pathophysiology of sperm dysfunction with each MetS component were described. Adopting a healthy lifestyle appears to be the single most important intervention to prevent the unwanted effects of MetS on men’s health and fertility. Further studies addressing the components of MetS and their impact on male reproduction are required to enhance our understanding of the underlying pathophysiology and to propose new methods for therapeutic intervention.DyslipidemiasGlucose intoleranceHypertensionmaleMetabolic syndromeObesitymale Infertility
spellingShingle Ana Dias Martins
Ahmad Majzoub
Ashok Agawal
Metabolic Syndrome and Male Fertility
The World Journal of Men's Health
Dyslipidemias
Glucose intolerance
Hypertension
male
Metabolic syndrome
Obesity
male Infertility
title Metabolic Syndrome and Male Fertility
title_full Metabolic Syndrome and Male Fertility
title_fullStr Metabolic Syndrome and Male Fertility
title_full_unstemmed Metabolic Syndrome and Male Fertility
title_short Metabolic Syndrome and Male Fertility
title_sort metabolic syndrome and male fertility
topic Dyslipidemias
Glucose intolerance
Hypertension
male
Metabolic syndrome
Obesity
male Infertility
work_keys_str_mv AT anadiasmartins metabolicsyndromeandmalefertility
AT ahmadmajzoub metabolicsyndromeandmalefertility
AT ashokagawal metabolicsyndromeandmalefertility