Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ

Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ

LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in numerous cellular functions, including cell death, signaling, tumor suppression, and viral infection. LC8 binds intrinsically disordered proteins (IDPs), and although several of these contain multiple LC8 binding...

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Bibliographic Details
Main Authors: Douglas R. Walker, Kayla A. Jara, Amber D. Rolland, Coban Brooks, Wendy Hare, Andrew K. Swansiger, Patrick N. Reardon, James S. Prell, Elisar J. Barbar
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
hub proteins
intrinsic disorder
multivalency
transcription factor
linker length
heterogeneity
Online Access:https://www.mdpi.com/2218-273X/13/3/404

Internet

https://www.mdpi.com/2218-273X/13/3/404

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