Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy

Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy

Abstract Background Human periodontal ligament stem cells (hPDLSCs) have a superior ability to promote the formation of new bones and achieve tissue regeneration. However, mesenchymal stem cells (MSCs) are placed in harsh environments after transplantation, and the hostile microenvironment reduces t...

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Bibliographic Details
Main Authors: Qingru Niu, Huan Chen, Qianmin Ou, Shuqing Yang, Yingying Peng, Yunyi Xie, Le Yu, Zhilan Cheng, Yang Cao, Yan Wang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Klotho
Human periodontal ligament stem cells (hPDLSCs)
Macrophage; Stem cell transplantation
Bone regeneration
Autophagy
Online Access:https://doi.org/10.1186/s13018-023-03849-8

Internet

https://doi.org/10.1186/s13018-023-03849-8

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