Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line

Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line

We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects of such compounds on amyloid precursor protein (APP) accumulation in...

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Main Authors: ANDRÉA C PAULA LIMA, CHRISTIAN ARRIAGADA, RODRIGO TORO, ANA MARÍA CÁRDENAS, RAÚL CAVIEDES, SERGIO T FERREIRA, PABLO CAVIEDES
Format: Article
Language:English
Published: BMC 2008-01-01
Series:Biological Research
Subjects:
Alzheimer's disease
Down syndrome
intracellular amyloid
murine trisomy 16
small molecule inhibitors
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200001

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200001

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