Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Abstract Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface. Overactivation of this system contributes to thrombosis and inflammation in numerous diseas...

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Bibliographic Details
Main Authors: Pradeep K. Singh, Zu‐Lin Chen, Katharina Horn, Erin H. Norris
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
clotting factors
contact system
intrinsic coagulation
kallikrein
kininogen
Online Access:https://doi.org/10.1002/rth2.12815

Internet

https://doi.org/10.1002/rth2.12815

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