Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71

Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71

Hand, foot and mouth disease (HFMD) is a childhood disease caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Capsid loops are important epitopes for EV-A71 and CV-A16. Seven chimeric EV-A71 (ChiE71) involving VP1 BC (45.5% similarity), DE, EF, GH and HI loops, VP2 EF loop and VP3 G...

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Bibliographic Details
Main Authors: Xiu Hui Tan, Wei Lim Chong, Vannajan Sanghiran Lee, Syahril Abdullah, Kartini Jasni, Saiful Qushairi Suarni, David Perera, I-Ching Sam, Yoke Fun Chan
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Vaccines
Subjects:
enterovirus A71
coxsackievirus A16
enterovirus
hand
foot and mouth disease
capsid loop
Online Access:https://www.mdpi.com/2076-393X/11/8/1363

Internet

https://www.mdpi.com/2076-393X/11/8/1363

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