Nature-Inspired <i>O</i>-Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress

Nature-Inspired <i>O</i>-Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress

Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing a concomitant anti-oxidant activity through dual-a...

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Bibliographic Details
Main Authors: Lidia Ciccone, Giovanni Petrarolo, Francesca Barsuglia, Carole Fruchart-Gaillard, Evelyne Cassar Lajeunesse, Adeniyi T. Adewumi, Mahmoud E. S. Soliman, Concettina La Motta, Elisabetta Orlandini, Susanna Nencetti
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomolecules
Subjects:
aldose reductase
aldose reductase inhibitors
anti-oxidants
benzaldehyde <i>O</i>-benzyl oximes
multifunctional compounds
Online Access:https://www.mdpi.com/2218-273X/12/3/448

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https://www.mdpi.com/2218-273X/12/3/448

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