Micro-CT-derived ventilation biomarkers for the longitudinal assessment of pathology and response to therapy in a mouse model of lung fibrosis

Abstract Experimental in-vivo animal models are key tools to investigate the pathogenesis of lung disease and to discover new therapeutics. Histopathological and biochemical investigations of explanted lung tissue are currently considered the gold standard, but they provide space-localized informati...

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Bibliographic Details
Main Authors: Francesca Pennati, Ludovica Leo, Erica Ferrini, Nicola Sverzellati, Davide Bernardi, Franco Fabio Stellari, Andrea Aliverti
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-30402-8