Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences

Abstract Background Genetic variability in the cytochrome P450 CYP2C9 constitutes an important predictor for efficacy and safety of various commonly prescribed drugs, including coumarin anticoagulants, phenytoin and multiple non-steroidal anti-inflammatory drugs (NSAIDs). A global map of CYP2C9 vari...

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Bibliographic Details
Main Authors: Yitian Zhou, Lenka Nevosadová, Erik Eliasson, Volker M. Lauschke
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Human Genomics
Subjects:
Pharmacogenomics
Precision medicine
Allele frequency
Metabolizer phenotype
Precision public health
Online Access:https://doi.org/10.1186/s40246-023-00461-z

Internet

https://doi.org/10.1186/s40246-023-00461-z

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